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KMID : 1098420070150030162
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Korean Journal of Medicinal Crop Science
2007 Volume.15 No. 3 p.162 ~ p.169
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Enhancement of Immune Activities of Kadsura Japonica Dunal. through Conventional Fermentation Process
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Kim Cheol-Hee
Kwon Min-Cheol
Kim Hyo-Sung
Ahn Ju-Hee
Chio Geun-Pyo
Choi Young-Beom
Ko Jung-Rim
Lee Hyeon-Yong
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Abstract
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Immune activities of two different extracts of Kadsura japonica Dunal. by typical extraction processes using water and ethanol at 60^{circ}C and 100 ^{circ}C were compared to them by ultrasofication system and through traditional fermemtation process. The fermented broth Kadsura japonica Dunal. definitely improved the growth of human B and T cell up to 30% and 22%, respectively, compared to the control. The secretion of TNF-{alpha} and IL-60 was also enhanced by the addition of the fermented broth, up to 35%. NK cell activation was significantly improved up to 1.4 times higher than the case of adding other extracts. It was also found that this broth could yield higher nitric oxide production from macrophage than Lipopolysaccharides (LPS). It can be concluded that Kadsura japonica has immune activities and, in general, the culture broth from a conventional fermentation has higher immune activities, possibly by yielding immuno-modulatory compounds, not existed in typcial extraction systems as the result of HPLC analysis.
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KEYWORD
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Kadsura Japonica Dunal., fermentation broth, immune activity
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